Molecular identification of IgE-dependent histamine-releasing factor as a B cell growth factor.

HRF-Interacting Molecules

Histamine-releasing factor (HRF), also termed translationally controlled tumor protein (TCTP) and fortilin, is a highly conserved, multi-functional protein. This protein within a cell plays a critical role in the fundamental processes of cell-cycle progression, proliferation, survival, and malignant transformation. The same protein, despite the lack of signal sequence, is secreted through a non...

Identification of a histamine release inhibitory factor produced by human mononuclear cells in vitro.

Human mononuclear cells (MNC) secrete histamine-releasing factor(s) (HRF) when cultured in vitro. HRF induces the release of histamine and other mediators from basophils and mast cells. We have shown that MNC also produced a histamine release inhibitory factor (HRIF), and that the synthesis is augmented by culture with physiologic concentrations of histamine (10(-10) to 10(-6) M) and by the mit...

Monocyte chemotactic and activating factor is a potent histamine-releasing factor for basophils.

Monocyte chemotactic and activating factor (MCAF) is a recently cloned cytokine that causes chemotaxis of basophils. In our pursuit of cytokines affecting basophil function, we studied the effect of MCAF on histamine secretion from basophils. Leukocytes from 20 donors, 10 allergic and 10 normal subjects, were studied. MCAF caused dose-dependent release of histamine at concentrations of 10(-8) a...

Histamine-Releasing Factor by Macrophages Homolog of a Human IgE-Dependent Mouse Stimulates Synthesis and Secretion of a Macrophage Colony-Stimulating Factor

Histamine-Releasing Factor and TCTP

IgE-mediated activation of mast cells and basophils underlies allergic diseases such as asthma. Since Thueson et al. first described an activity from cultured peripheral blood mononuclear cells that induced the release of histamine from basophils [1], histamine-releasing activities have been studied for more than 30 years. In addition to several cytokines and chemokines with this activity, an u...